Arron Afflalo sank six 3-point shots and scored 24 points for the Nuggets, who played without all-star Carmelo Anthony, sidelined with an ankle sprain.
Billups contributed 11 assists and Nene had 17 points and four steals for Denver, which built a sizeable lead and withstood a late 11-3 run by Charlotte.
Stephen Jackson had 22 points and Gerald Wallace 20 for the Bobcats.
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